Few of our publications in Data Science, Biostatistics and Medical Devices:

  • Polpitiya, Ashoka D; Qian, Wei-Jun; Jaitly, Navdeep; Petyuk, Vladislav A; Adkins, Joshua N; Camp, David G; Anderson, Gordon A; Smith, Richard D; ,DAnTE: a statistical tool for quantitative analysis of-omics data,Bioinformatics,24,13,1556-1558,2008,Oxford University Press
  • Metz, Thomas O; Qian, Wei-Jun; Jacobs, Jon M; Gritsenko, Marina A; Moore, Ronald J; Polpitiya, Ashoka D; Monroe, Matthew E; Camp Ii, David G; Mueller, Patricia W; Smith, Richard D; ,Application of proteomics in the discovery of candidate protein biomarkers in a diabetes autoantibody standardization program sample subset,Journal of proteome research,7,2,698-707,2007,American Chemical Society
  • McDunn, Jonathan E; Husain, Kareem D; Polpitiya, Ashoka D; Burykin, Anton; Ruan, Jianhua; Li, Qing; Schierding, William; Lin, Nan; Dixon, David; Zhang, Weixiong; ,Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram,PloS one,3,2,e1564,2008,Public Library of Science
  • Lewis, Nathan E; Hixson, Kim K; Conrad, Tom M; Lerman, Joshua A; Charusanti, Pep; Polpitiya, Ashoka D; Adkins, Joshua N; Schramm, Gunnar; Purvine, Samuel O; Lopez‐Ferrer, Daniel; ,Omic data from evolved E. coli are consistent with computed optimal growth from genome‐scale models,Molecular systems biology,6,1,390,2010,EMBO Press
  • Qian, Wei-Jun; Liu, Tao; Petyuk, Vladislav A; Gritsenko, Marina A; Petritis, Brianne O; Polpitiya, Ashoka D; Kaushal, Amit; Xiao, Wenzhong; Finnerty, Celeste C; Jeschke, Marc G; ,Large-scale multiplexed quantitative discovery proteomics enabled by the use of an 18O-labeled “universal” reference sample,Journal of proteome research,8,1,290-299,2008,American Chemical Society
  • Yang, Feng; Wu, Si; Stenoien, David L; Zhao, Rui; Monroe, Matthew E; Gritsenko, Marina A; Purvine, Samuel O; Polpitiya, Ashoka D; Tolic, Nikola; Zhang, Qibin; ,Combined pulsed-Q dissociation and electron transfer dissociation for identification and quantification of iTRAQ-labeled phosphopeptides,Analytical chemistry,81,10,4137-4143,2009,American Chemical Society
  • McDunn, Jonathan E; Turnbull, Isaiah R; Polpitiya, Ashoka D; Tong, Alice; MacMillan, Sandra K; Osborne, Dale F; Hotchkiss, Richard S; Colonna, Marco; Cobb, J Perren; ,Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis,Journal of the American College of Surgeons,203,3,375. e1-375. e39,2006,Elsevier
  • Polpitiya, Ashoka D; Dayawansa, Wijesuriya P; Martin, Clyde F; Ghosh, Bijoy K; ,Geometry and control of human eye movements,IEEE Transactions on Automatic control,52,2,170-180,2007,IEEE
    Polpitiya, Ashoka D; McDunn, Jonathan E; Burykin, Anton; Ghosh, Bijoy K; Cobb, J Perren; ,Using systems biology to simplify complex disease: immune cartography,Critical care medicine,37,1 0,S16,2009,NIH Public Access
  • Wasbrough, Elizabeth R; Dorus, Steve; Hester, Svenja; Howard-Murkin, Julie; Lilley, Kathryn; Wilkin, Elaine; Polpitiya, Ashoka; Petritis, Konstantinos; Karr, Timothy L; ,The Drosophila melanogaster sperm proteome-II (DmSP-II),Journal of proteomics,73,11,2171-2185,2010,Elsevier
  • Petyuk, Vladislav A; Mayampurath, Anoop M; Monroe, Matthew E; Polpitiya, Ashoka D; Purvine, Samuel O; Anderson, Gordon A; Camp, David G; Smith, Richard D; ,DtaRefinery, a software tool for elimination of systematic errors from parent ion mass measurements in tandem mass spectra data sets,Molecular & Cellular Proteomics,9,3,486-496,2010,American Society for Biochemistry and Molecular Biology
  • Ghosh, Bijoy K; Polpitiya, Ashoka D; Wang, Wenxue; ,Bio-inspired networks of visual sensors, neurons, and oscillators,Proceedings of the IEEE,95,1,188-214,2007,IEEE
  • Stöckel, Jana; Jacobs, Jon M; Elvitigala, Thanura R; Liberton, Michelle; Welsh, Eric A; Polpitiya, Ashoka D; Gritsenko, Marina A; Nicora, Carrie D; Koppenaal, David W; Smith, Richard D; ,Diurnal rhythms result in significant changes in the cellular protein complement in the cyanobacterium Cyanothece 51142,PloS one,6,2,e16680,2011,Public Library of Science
  • Checchia, Paul A; Schierding, William; Polpitiya, Ashoka; Dixon, David; MacMillan, Sandy; Muenzer, Jared; Stromberg, Paul; Coopersmith, Craig M; Buchman, Timothy G; Cobb, J Perren; ,Myocardial transcriptional profiles in a murine model of sepsis: Evidence for the importance of age,Pediatric Critical Care Medicine,9,5,530-535,2008,LWW
  • Polpitiya, Ashoka D; Ghosh, Bijoy K; ,Modelling and control of eye-movement with musculotendon dynamics,Proceedings of the 2002 American Control Conference (IEEE Cat. No. CH37301),3,,2313-2318,2002,IEEE
  • Ham, Bryan M; Jayachandran, Hemalatha; Yang, Feng; Jaitly, Navdeep; Polpitiya, Ashoka D; Monroe, Matthew E; Wang, Ling; Zhao, Rui; Purvine, Samuel O; Livesay, Eric A; ,Novel Ser/Thr protein phosphatase 5 (PP5) regulated targets during DNA damage identified by proteomics analysis,Journal of proteome research,9,2,945-953,2009,American Chemical Society
  • Polpitiya, Ashoka D; Ghosh, Bijoy K; Martin, Clyde F; Dayawansa, Wijesooriya P; ,Mechanics of the eye movement: geometry of the listing space,Proceedings of the 2004 American Control Conference,1,,323-328,2004,IEEE
  • Polpitiya, Ashoka D; Nenadic, Zoran; Ghosh, Bijoy K; ,Optimal filtering in biological neural networks,Proceedings of the 2001 American Control Conference.(Cat. No. 01CH37148),5,,3539-3542,2001,IEEE
    Polpitiya, Ashoka D; Ghosh, Bijoy K; Martin, Clyde F; Schovanec, Lawrence; ,Modeling and control of 3d eye movement with musculotendon dynamics,IFAC Proceedings Volumes,35,1,7-12,2002,Elsevier
  • Karpievitch, Yuliya V; Polpitiya, Ashoka D; Anderson, Gordon A; Smith, Richard D; Dabney, Alan R; ,Liquid chromatography mass spectrometry-based proteomics: biological and technological aspects,The annals of applied statistics,4,4,1797,2010,NIH Public Access
  • Elvitigala, Thanura R; Polpitiya, Ashoka D; Wang, Wenxue; Stockel, Jana; Khandelwal, Abha; Quatrano, Ralph S; Pakrasi, Himadri B; Ghosh, Bijoy K; ,High-throughput biological data analysis,IEEE Control Systems Magazine,30,6,81-100,2010,IEEE
  • Ghosh, Bijoy K; Polpitiya, Ashoka; Wang, Wenxue; ,Bio-Inspired Sensor Networks in Formation Sensing, Multi Sensor Fusion and Scene Recognition.
  • Polpitiya, Ashoka D; Jaitly, Navdeep; Petritis, Konstantinos; ,A Tool for Quantitative Analysis of Proteomics Data,
  • Metz, Thomas O; Qian, Wei-Jun; Jacobs, Jon M; Polpitiya, Ashoka D; David, G Camp II; Smith, Richard D; ,Serum markers for type II diabetes mellitus, 2014,US Patent 8,673,644

Few of our publications in Pharmaceutical Process Research & Development:

Selected Patents:

  1. Low PS, Kularatne SA. PSMA Binding Ligand-Linker Conjugates and Methods for Using. 2008289108, 200880111794, 203998, 583931, 600085, 2014-125603, 8907058 
  2. Low PS, Kularatne SA. Positron emission tomography methods. 9180215
  3. Low PS, Wei H, Kularatne SA. Ex vivo flow cytometry methods and device. 8685752, 9279813
  4.  Low PS, Kularatne SA. Composition and Methods for Treating Inflammatory Disease, US20090012009
  5. Low PS, Kularatne SA. Vitamin – hapten conjugate inflammation therapy. US2007/64871
  6. Low PS, Kularatne SA, Mahalingam S. Synthesis and composition of amino acid linking groups and conjugated to compounds used for the targeted imaging of tumors. 14/010098, 14/207130, 14/715799, 14/953928
  7.  Kularatne SA. Synthesis and composition of amino acid linking groups and conjugated to compounds used for the targeted imaging of tumors.  US14/953928, US15/259719
  8. Kularatne SA, Gagare P, Norshi M. Methods of Manufacture and Synthesis of Amino Acid Linking Groups       Conjugated To Compounds Used For Targeted Imaging of Tumors. 14/046916
  9. Low PS, Kularatne SA, Kelderhouse LE, Mahalingam S. Methods of Imaging Inflammatory Diseases by Ligand Conjugated to Fluorescent Compounds. 14/135099
  10. Kularatne SA, Gagare P, Low PS. Synthesis and Composition of Photodynamic Therapeutic Agents for the Targeted treatment of cancer and inflammatory Diseases. 15/257566
  11. Kularatne SA, Gagare P, Low PS. PSMA-Targeted NIR Dyes and Their Uses. 14/937169, 14/939915
  12. Kularatne SA, Thomas M. PSMA-Targeted NIR Dyes and Their Uses 16/126,140
  13. Kularatne SA, Gagare P. Methods of manufacturing PSMA-Targeted NIR Dyes. 15/699124
  14. Kularatne SA, Gagare P, Kanduluru A. CA IX-Targeted NIR Dyes and Their Uses. 62/309412
  15. Kularatne SA, Gagare P, Norshi M. Choecystokinin 2 Receptor Targeted NIR Imaging and Use Thereof. 62/385338

Selected Publications: 

  • Evaluation of Novel Prostate-Specific Membrane Antigen-Targeted Near-Infrared Imaging Agent for Fluorescence-Guided Surgery of Prostate Cancer. Kularatne SA, Thomas M, Myers CH, Gagare P, Kanduluru AK, Crian CJ, Cichocki BN. Clin Cancer Res. 2018 Sep 10. doi: 10.1158/1078-0432.CCR-18-0803.
  • Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer. Mahalingam SM, Kularatne SA, Myers CH, Gagare P, Norshi M, Liu X, Singhal S, Low PS. J Med Chem. 2018 Oct 19. doi: 10.1021/acs.jmedchem.8b01115.
  • A CXCR4-targeted site-specific antibody-drug conjugate. Kularatne SA, Deshmukh V, Ma J, Tardif V, Lim RK, Pugh HM, Sun Y, Manibusan A, Sellers AJ, Barnett RS, Srinagesh S, Forsyth JS, Hassenpflug W, Tian F, Javahishvili T, Felding-Habermann B, Lawson BR, Kazane SA, Schultz PG. Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11863-7.
  • Recruiting cytotoxic T cells to folate-receptor-positive cancer cells. Kularatne SA, Deshmukh V, Gymnopoulos M, Biroc SL, Xia J, Srinagesh S, Sun Y, Zou N, Shimazu M, Pinkstaff J, Ensari S, Knudsen N, Manibusan A, Axup J, Kim C, Smider V, Javahishvili T, Schultz PG. Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12101-12104.
  • Comparative analysis of folate derived PET imaging agents with [(18)F]-2-fluoro-2-deoxy-d-glucose using a rodent inflammatory paw model. Kularatne SA, Bélanger MJ, Meng X, Connolly BM, Vanko A, Suresch DL, Guenther I, Wang S, Low PS, McQuade P, Trotter DG. Mol Pharm. 2013 Aug 5;10(8):3103-11.
  • Characterization of in vivo disulfide-reduction mediated drug release in mouse kidneys. Yang JJ, Kularatne SA, Chen X, Low PS, Wang E. Mol Pharm. 2012 Feb 6;9(2):310-7.
  • Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs. Kularatne SA, Venkatesh C, Santhapuram HK, Wang K, Vaitilingam B, Henne WA, Low PS. J Med Chem. 2010 Nov 11;53(21):7767-77.
  • Targeting of nanoparticles: folate receptor. Kularatne SA, Low PS. Methods Mol Biol. 2010;624:249-65.
  • Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Thomas M, Kularatne SA, Qi L, Kleindl P, Leamon CP, Hansen MJ, Low PS. Ann N Y Acad Sci. 2009 Sep;1175:32-9.
  • Folate-targeted therapeutic and imaging agents for cancer. Low PS, Kularatne SA. Curr Opin Chem Biol. 2009 Jun;13(3):256-62.
  • Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand. Kularatne SA, Wang K, Santhapuram HK, Low PS. Mol Pharm. 2009 May-Jun;6(3):780-9
  • Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents. Kularatne SA, Zhou Z, Yang J, Post CB, Low PS. Mol Pharm. 2009 May-Jun;6(3):790-800
  • Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands. He W, Kularatne SA, Kalli KR, Prendergast FG, Amato RJ, Klee GG, Hartmann LC, Low PS. Int J Cancer. 2008 Oct 15;123(8):1968-73.
  • Synthesis and activity of a folate peptide camptothecin prodrug. Henne WA, Doorneweerd DD, Hilgenbrink AR, Kularatne SA, Low PS. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5350-5.